Digby was the son of Sir Robert Digby of Coleshill, Warwickshire, and Lettice FitzGerald, of Geashill, Ireland, granddaughter of Gerald FitzGerald, 11th Earl of Kildare.
Digby notably served as Governor of King's County in Ireland.
In 1620, he was raised to the Peerage of Ireland as Baron Digby, of Geashill.
He married, firstly, Lady Sarah Boyle, daughter of Richard Boyle, 1st Earl of Cork, and Catherine Fenton; this marriage produced a son, Kildare Digby (c. 1627 – 1661).
Digby died in 1642 and was succeeded in the barony by his son Kildare.