She was the author of more than 100 research articles and held six patents in the areas of human-computer interaction, artificial intelligence, and collaboration.

Despite a rapid physical deterioration, Wolf was still able to communicate with the world via electronic sensory equipment, including a sophisticated brain-computer interface.

[3] Remarkably, with almost no voluntary physical functions remaining, she published novel research into the fine-scale abilities of ALS patients.

Both continued on to graduate school at Brown University, where Catherine focused her research on the way that children perceive speech.

[5] After Brown, Wolf completed additional postgraduate work at MIT before entering the workforce as a full-time researcher.

In response to behaviors she observed, she designed and tested new interface systems in which speech and handwritten words could be converted to digital information.

She was aware that she might lose the ability to communicate with her eyebrows, so she worked with scientists on an EEG-based interface system for herself, if that day came.

With such a setup in place, Wolf hoped to communicate words simply by focusing her thoughts on one letter at a time.