She was the sibling of Maria Elizabeth of Pfalz-Zweibrücken and Adolph John II, Count Palatine of Kleeburg and Gustav, Duke of Zweibrücken.
Her father, Adolph John I, resided permanently in exile from the Swedish royal court at Stegeborg Castle, after his unsuccessful career and the great reduction of Charles XI had left the family in poor financial circumstances.
Their parents were described as bitter toward the royal house, and reportedly channelized their frustration in their behavior toward their children, who they treated worse enough to attract dislike even by the standard of the day.
The 1 November 1687, the two sisters and their younger brother Gustav ran away from home with the assistance of the clerk Matthias Rigneer and the footman Petter.
After the report, Charles XI offered to finance a trip abroad for the male siblings and give the female ones positions at court, but the Duke declined all efforts to violate his parental authority.
In July 1688, the three siblings ran away a second time, and although the servants of their father caught up with them, they allowed them to proceed to the royal court in Stockholm despite their orders to stop them.