[1] Her first book was Alice in Bed (1983), which was followed by To the Birdhouse (1990), Rameau's Niece (1993), The Love Letter (1995) and The Evolution of Jane (1998).

Rameau's Niece was filmed as The Misadventures of Margaret starring Parker Posey.

Schine also wrote a Sunday Serial for The New York Times Sunday Magazine, The Dead and the Naked, which ran beginning September 9, 2007, and was published in Italy as "Miss S." One character, Miss Skattergoods, also appears in The Love Letter.

Schine's work appears frequently in The New York Review of Books, The New Yorker and other publications.

Reviewer Leah Rozen in People magazine dubbed her "a modern-day Jewish Jane Austen.