[4] In March 1998, the Sisters of St. Francis of the Immaculate Heart of Mary in Hankinson, North Dakota transferred sponsorship of a hospital and eight clinics to CHI.

[13] In January 2019, the KentuckyOne Health system decided to transition to the legacy of the Sisters of Charity of Nazareth, Lexington's first hospital.

[15][16] Colorado-based CHI is one of the nation's largest health systems, operating in 18 states and comprising 104 hospitals,[17] including four academic health centers and major teaching hospitals and 30 critical-access facilities; community health-services organizations; accredited nursing colleges; home-health agencies; and other facilities that span the inpatient and outpatient continuum of care.

Charity care and community benefit totaled more than $1.7 billion with the inclusion of the unpaid costs of Medicare.

Following the 2018 Stoneman Douglas High School shooting, in example; Catholic Health Initiatives was the lead filer, co-filing with the Adrian Dominican Sisters, of a shareholder resolution asking firearms manufacturer Sturm, Ruger & Co. to report to investors regarding the steps they are taking to reduce gun violence.

"[18][19][20][21][22][23] In January 2013, the hospital's defense lawyers provoked controversy when they defended against a wrongful death lawsuit by arguing that unborn fetuses should not be classed as persons.

[24] When the case was submitted to the three bishops of Colorado for review, they issued a joint statement which reiterated their commitment to defending human dignity against attacks.