[2] Before finishing college, Sadler was hired by WXIN, the Fox affiliate in Indianapolis to host the weekly segment "Youth Matters".

[3] For four years she hosted a nightly lifestyle segment called "The Bay Beat" and traveled frequently to Los Angeles and New York to conduct celebrity interviews.

Sadler continued acting in L.A. She played herself in Judd Apatow's Knocked Up, and appeared on General Hospital and Night Shift.

Live from the Red Carpet events, covering the Academy Awards, Golden Globes, Emmys, and more.

Guests have included Scarlett Johansson, Katie Couric, Molly Shannon, Rebecca Minkoff and many other notable women.

[7] Sadler is the international spokesperson for the Women Like Us Foundation,[8] an organization her mother co-created after writing a book of the same name.

[14] Sadler began dating British film producer Rhys David Thomas after meeting at a charity event in Los Angeles in May 2010.

[17] On July 13, 2021, Catt Sadler stated she was fully vaccinated, but she was experiencing intense symptoms after a breakthrough infection of contracting the SARS-CoV-2 Delta variant.