[12] McNally made her WTA Tour main-draw debut at the 2017 Western & Southern Open in the doubles tournament, partnering with Alexa Glatch.

[11] At the end of July and beginning of August, McNally recorded her first WTA tournament main-draw singles wins with a run to the semifinal at the Washington Open, beating Zhu Lin, Christina McHale and fourth seed Hsieh Su-wei.

[18] She was awarded a wildcard into her home tournament, the Cincinnati Open,[6] where she played her first-round match on center court, but lost to Elise Mertens.

[29] At Luxembourg the following week, McNally lost in the first round to Jeļena Ostapenko,[30] but went through to the final of the doubles with Gauff, beating Misaki Doi and Makoto Ninomiya, No.

[31] They beat second seeds Kaitlyn Christian and Alexa Guarachi in the final to secure their second WTA tournament title, with a career win–loss record of 12–2 as a team.

[33][34] At the Australian Open, she won her qualifying matches, entering the main draw, where she defeated Sam Stosur in the first round, before losing to Zhang Shuai.

In doubles, McNally and Gauff recorded their best result at a Grand Slam tournament, reaching the quarterfinals before falling to second seeded Kristina Mladenovic and Tímea Babos in two sets.

[37] Following the break caused by the COVID-19 pandemic, McNally took part in the Western & Southern Open, which was moved from her home town of Cincinnati to New York, losing in the first round to Alizé Cornet.

[43] In the one-off MUSC Health Open later that month, also in Charleston, she was beaten in the first round of the singles by Shelby Rogers, but partnered with Hailey Baptiste to win the doubles tournament, beating Australian duo Ellen Perez and Storm Sanders in the final.

[citation needed] At the St. Petersburg Trophy in February, McNally teamed up with Anna Kalinskaya to win the doubles title, beating Polish Alicja Rosolska and New Zealander Erin Routliffe in the final; it was her fifth on the WTA Tour.

[55] In November, she won her first WTA 125 title at the Midland Classic defeating Anna-Lena Friedsam in straight sets and made her top 100 debut in singles, at world No.

[56][57] At the Mérida Open, McNally reached her first WTA Tour semifinal defeating third seed Zhu Lin,[58] Katie Volynets[59][60] and Kimberly Birrell.

[citation needed] At the same tournament, playing with Diane Parry, she won her seventh doubles title, beating Wang Xinyu and Wu Fang-hsien in the final.

[66] She briefly returned to the tour in February, playing at the Transylvania Open, where she won the doubles title with Asia Muhammad,[67] as well as tournaments in Linz and Puerto Vallarta, before undergoing surgery on her elbow at the renowned Andrews Sports Medicine and Orthopaedic Center in Alabama in March.

[68] She made her comeback in November 2024 at the WTA 125 Dow Tennis Classic in Midland, Michigan, defeating Leonie Küng in the first round,[69] before losing her next match to Alycia Parks.

[70] The following month, McNally won her first title since her return to action at the Tampa ITF W50 and as a result jumped 223 places in the WTA singles rankings to world No.

[72] Only main-draw results in WTA Tour, Grand Slam tournaments, Fed Cup/Billie Jean King Cup and Olympic Games are included in win–loss records.