Ceccy Twum released her first album Me Gyefo ne Yesu in 2005, which brought her into the limelight.

She has collaborated and performed on major platforms with several gospel musicians, including Mercy Chinwo, Joe Mettle, Ohemaa Mercy, MOG Music, Joyce Blessing, Nathaniel Bassey, Sinach, Frank Edwards, Empress Gifty.

[6][7][8] Ceccy has many hits songs including Victory, Di Wo Hene, Your Grace, Amen.

In 2018 her major hit single Jehovah earned her a nomination at the Vodafone Ghana Music Awards as the Gospel song of the year.

[9][10] She was also nominated for Artiste Of Excellence West Africa at the African Music And Media Awards.