A critic of the extractivist policies of President Evo Morales, in 2019, Requena ran for a seat in the Senate as part of the opposition Civic Community's all-female roster of senatorial candidates.

[6] During this time and after, Requena also undertook graduate studies at home and abroad; she received a postgraduate diploma in socio-environmental projects from the Latin American Forum of Environmental Sciences in Argentina and completed a second master's in diplomacy and international relations at the Diplomatic Academy of Bolivia.

[5] An avid environmentalist from a young age,[4] Requena served on the directorate of the Bolivian Association for the Defense of Nature between 1992 and 1993, first as coordinator for communication, lobbying, and public awareness and later as the organization's executive secretary.

"The government of Evo Morales, which presents itself internationally as a defender of Mother Earth, will remain in Bolivian history as the regime that promoted radical and devastating extractivism," she stated.

"[4] She became increasingly politically active following the abolishment of presidential term limits, joining more than 180 other prominent intellectuals in penning a roadmap for the country's transition from an "authoritarian and corporate" state towards a more democratic one.

[4] Among the primary pillars of CC's political platform were democracy0 and environmentalism but also feminism and women's rights,[12] a fact that led the alliance to nominate an all-female slate of senatorial candidates.

[13] Requena was selected to represent the La Paz Department in the Senate,[14][15] a choice potentially brought about at the suggestion of her spouse, José Antonio Quiroga, CC's then-campaign coordinator.