For her work on Saturday Night Live, Strong was nominated for Outstanding Supporting Actress in a Comedy Series at the 72nd and 73rd Primetime Emmy Awards.

[6] She is the daughter of Penelope and William "Bill" Strong, who worked as an Associated Press bureau chief and as of 2013 ran his own public-relations firm.

[20] In 2020, Strong was nominated for her first Primetime Emmy Award for Outstanding Supporting Actress in a Comedy Series for her work on the show.

[26] Strong followed up on the commentary a year later, during a Weekend Update sketch on the November 5, 2022, episode, appearing as "Tammy the Trucker on Gas Prices and Definitely Not Abortion" before the 2022 midterm elections.

She also took shots at the U.S. Secret Service, host location the Washington Hilton, Brian Williams, Sarah Koenig and the state of Indiana.

[39] In 2016, she guest starred as Samantha Stevens in TBS's Angie Tribeca and Catherine Hobart in Fox's Scream Queens.

[40][41] The book addresses "the challenges of beginning in a relationship during the pandemic; the pain of losing family and friends; the pivotal events of her life that shaped her; and the importance of gratitude for each passing day.

"[42] It developed from an essay she wrote about grieving the loss of her cousin Owen to brain cancer in the middle of the COVID-19 pandemic that was first published on Vulture.com in 2020.

Developed by Cinco Paul and Ken Daurio, and produced by SNL's Lorne Michaels, the series centers on a couple (played by Strong and Keegan-Michael Key) stuck in a 1940s studio musical town until they find "true love".

[46][47] Strong made her New York stage debut in an Off Broadway revival of Jane Wagner's one-woman play The Search for Signs of Intelligent Life in the Universe, which starred Lily Tomlin in 1985.

[49][50] It was then announced in December 2023, that Strong would co-star in the off Broadway play Brooklyn Laundry, which opened at the New York Center on February 28, 2024.