[1] By 1976, Freytes was working in the department of reading and language at the BU School of Education and was a member of The Society for the Study of the Multi-Ethnic Literature of the United States (MELUS).
[4] In 2013, Freytes was a member of Puerto Rico Governor Alejandro Garcia Padilla's transitional team before he took office as governor; Garcia Padilla contacted her directly about becoming interim president of the University of Puerto Rico (UPR) before she was named to the position.
[4] Freytes has held multiple administrative positions at UPR, including vice president for academic affairs.
[7][8] During her second term as interim president, Freytes focused on managing the university's financial difficulties, developing a new strategic plan for 2016 to 2021, and ensuring compliance with accreditation standards from the Middle States Commission on Higher Education.
[8][7] Freytes Gonzalez announced on February 16, 2017, that she and other UPR leaders were renouncing from their positions, a move that was investigated by the Puerto Rican senate.