Castro's artistic career was inspired from a meeting with the painter Manuel Antonio Caro who, after seeing her work, recommended she go to Santiago to study at the Academia de Pintura (es).
In 1889, it won an award and was acquired by the Chilean National Museum of Fine Arts.
On her return, these new works prompted the government to give her a study grant and she went back to Europe in 1904.
Castro eventually won praise from Parisian critics and exhibited frequently at the Salon.
She returned to Chile in 1927 and died three years later,[1] having paved the way for other female artists such as Rebeca Matte, the Mira sisters, Aurora and Magdalena.