Imrie played Fighter Pilot Bravo 5 in Star Wars: Episode I – The Phantom Menace,[10] Matron in St Trinian's (2007), Claudia Bing in Absolutely Fabulous: The Movie (2016), Victoria Watkins in A Cure for Wellness (2016), Bif in Finding Your Feet (2017), Vice-Chancellor in Mamma Mia!

[11] Imrie's television credits include Upstairs, Downstairs, Bergerac, The Nightmare Man, Oranges Are Not the Only Fruit, Casualty, Absolutely Fabulous, and The Darling Buds of May.

[11] Imrie's other roles include Still Game, Cloud Howe, Taggart,[12] Oranges Are Not the Only Fruit, and Blue Black Permanent (1992).

[10] After appearing as a chorus girl in many a pantomime, in 1975 Imrie got a job as an Assistant Stage Manager and understudy in the Royal Shakespeare Company with Glenda Jackson playing Hedda Gabler, directed by Trevor Nunn, on a world tour.

[15] Also in the company at that time were Patrick Stewart, Timothy West, Peter Eyre, Pam St Clement, Jennie Linden and Fidelis Morgan.

[17] In 2005, after a successful run at the King's Head Theatre, her one woman play Unsuspecting Susan written by Stewart Permutt transferred to 59E59 Theaters in New York.

In 1990 she appeared in Hangover Square at the Lyric Hammersmith with Dudley Sutton,[25] in Drama at Inish (2011) at the Finborough Theatre with Paul O'Grady,[26] and in her cabaret Laughing Matters[27] – all adapted and directed by Fidelis Morgan.

In 2010 Imrie played in Hay Fever,[28] and during the 2011–2012 season she appeared in Noises Off at The Old Vic and the West End, for which performance she was nominated for an Olivier Award.

[29] In 2016 Imrie re-united with Glenda Jackson after 41 years since their RSC world tour, playing a "grimly determined Goneril" in King Lear at The Old Vic.

Here We Go Again, Imrie achieved her first UK Top 40 single alongside Lily James with a cover of the ABBA song "When I Kissed the Teacher", which reached number 40 in August 2018.

[40] Angus appears as her on-screen son in Kingdom (2007–2009) and has acted in other productions, having studied drama and performance at the University of Warwick.

in October 2012 and discovered that an ancestor on her mother's side was William, Lord Russell, a Whig parliamentarian executed for treason in 1683, after being found guilty of conspiring against Charles II.