[1] Margherita's film credits include Boogeyman 2, Lucky Stiff, Cinderella III: A Twist in Time, and Opening Night.
Her television credits include NYPD Blue, Charmed, The District, On the Lot, The Suite Life on Deck, Major Crimes and Donny!.
The Variety reviewer wrote, "Also standing out is Lesli Margherita as Phyllis, Phil’s long-suffering snob of a wife, who gets every laugh effortlessly with her deadpan delivery.
[22] From January 19, 2020, to March 11, 2020, Lesli starred as Princess in the musical Emojiland at the Duke on 42nd Street theater in New York City.
[23][24] On September 24, 2024, the Gypsy Revival cast was released and revealed that she will be playing Tessie Tura on Broadway starting in November 2024.