Born in Abetone, Tuscany,[2] she was the youngest child in a family of nine[1] and earned her first Italian championship medal, a bronze in the slalom, in 1934.

In 1937 Seghi earned three national titles, her first victories at that level, by winning the slalom, downhill, and combined events.

[6] On the international level Seghi won gold in the slalom and silver in the combined event at the 1941 FIS Alpine World Ski Championships, but the results of the tournament were nullified by the International Ski Federation due to the limited participation from only German-friendly nations.

[1] She resumed skiing after World War II and next appeared at the 1948 Winter Olympics, where she finished fourth in both the women's downhill and combined, and joint-fourteenth (with Laila Schou Nilsen) in the slalom.

[2] She retired from active competition in 1956, shortly before the 1956 Winter Olympics, married a surgeon in 1970, and moved to Pistoia,[1] where she continued to ski into her 90s.