She competes in all alpine disciplines, with a focus on giant slalom and super-G. Brignone won the World Cup overall title in 2020, becoming the first Italian female to achieve this feat.

In December 2012, Brignone underwent surgery on her right ankle to remove a bothersome cyst,[10] and missed the rest of the 2013 season.

During the World Cup finals at Aspen in March 2017, Brignone won giant slalom to lead an Italian podium sweep, with teammates Sofia Goggia and Marta Bassino.

In March 2020, Brignone earned the overall crystal globe with 1378 points – ahead of Mikaela Shiffrin (1225) and Petra Vlhova (1189) – becoming the first and to date only Italian woman to win World Cup overall title.

[11] Through December 2023, Brignone has 23 World Cup victories and 60 podiums, with 32 in giant slalom, 16 in super-G, 6 in downhill, and 6 in combined.