Celio Piccolomini (1609–1681) was a Roman Catholic cardinal.

On 29 October 1656, he was consecrated bishop by Giulio Cesare Sacchetti, Cardinal-Bishop of Sabina, with Carlo de' Vecchi, Bishop of Chiusi, and Francesco Rinuccini, Bishop of Pistoia e Prato, serving as co-consecrators.

[1][2] He was named Apostolic Nuncio to France on 15 November 1656 and served until 30 August 1663.

He was the principal consecrator of François de Laval de Montmorency, Titular Bishop of Petra in Palaestina (1658); Bonaventura Cavalli, Bishop of Caserta (1668); and Vincenzo Maffia, Bishop of Patti (1671).

[2] This article about an Italian Catholic cardinal is a stub.