Giulio Cesare Sacchetti (1586 – 28 June 1663) was an Italian Catholic cardinal and was twice included in the French Court's list of acceptable candidates for the Papacy, in 1644 and 1655.

[citation needed]Marcello Sacchetti, was made depositary general and secret treasurer of the Apostolic Chamber in 1623 thanks to his relationship with Maffeo Barberini, who had just become Pope Urban VIII.

[2] Contemporary John Bargrave suggested Matteo's certainty stemmed from the fact that the Barberini (two of whom were cardinals and nephews of the previous Pope Urban VIII) had started referring to him as Your Eminence; a title reserved for cardinals, suggesting his brother's elevation to the papacy (and thus his own to the cardinalate) was imminent.

To this end they devised a rhyming ditty expressing: 'Don't make Sacchetti pope or Rome will fall to pieces'.

When Innocent X died, Sacchetti was again presented as the French candidate at the papal conclave of 1655 but when it became apparent that he did not have a majority, he asked Mazarin to give his support to Fabio Chigi, who was duly elected and took the name of Alexander VII.