[3] Its curriculum included courses in English, French, Greek, Latin, logic, rhetoric, ancient and modern history, mathematics, and natural, moral, and political philosophy.

[7] During the 1850s, enrollment reached 260, and the college constructed a large central building, which included classrooms, laboratories, literary society rooms, a library, a chapel, offices, and an auditorium with seating for over 2,000 people.

In 1906 the Louisiana Conference of the Methodist Episcopal Church, South, accepted an offer from the Shreveport Progressive League to relocate the college.

[12] Enrollment and course offerings increased during the 1920s, and Centenary received accreditation from the Southern Association of Colleges and Schools in 1925.

[15] In 1942, Centenary acquired a satellite campus, the former Dodd College, which served as a pre-flight training facility for air force cadets.

The Dr. Ed Leuck Academic Arboretum, located in the heart of campus, is home to more than 300 species of plant life.

[32] Centenary fields 20 intercollegiate athletic teams including football, baseball, basketball, cross country, golf, lacrosse, soccer, and swimming for men; and basketball, cross country, golf, gymnastics, soccer, softball, swimming, tennis, and volleyball for women.

The 1927 team featured wins over four powers in the Southwest Conference: Southern Methodist, Baylor, Rice, and Texas Christian.

[34] Head Coach Homer Norton left Centenary after the 1933 season, and success and fan interest dwindled.