The first graduation commencement for Centennial High School was held in the Spring of 2014 including both a valedictorian and a salutatorian.

Each grade level is assigned its own building cluster within the campus and has a designated lunch eating area.

The school employs eighty-two instructors, and has adopted a traditional seven-period scheduling format.

The namesake of the school is due to its opening coinciding with the 100-year anniversary of New Mexico's statehood on January 6, 1912.

Through the 2023–24 school year, Centennial has captured seven major athletic state championships.