[4] Known for its Advanced Placement (AP) program, the school's test scores regularly outperform state, national, and global averages.

The school was originally located downtown, one block from the Plaza in the space where City Hall and the Convention Center currently sit.

The new location on a hilltop above Yucca and Siringo roads was built and opened in 1966 where students slowly transitioned until the downtown campus was officially closed in 1977.

[12] In relation to its Advanced Placement (AP) program, Santa Fe High School's test scores regularly outperform state, national, and global averages.

Journalism students are also responsible for the publishing of daily school news videos to the Demon Tattler YouTube channel.

Another of the school's most dominant programs was its cross country team in the late 1970s and early '80s under coach John Alire, winning twelve state title trophies during this span.