With the exception of the aforementioned vocal music room, the entire building is fully wheelchair accessible, despite having been built 15 years before the Americans with Disabilities Act came into force.

After a few years, it was decided that the hassle of dealing with noise transmission between classrooms wasn't worth the positive effects of collaboration.

Because the school was designed to be open, adding walls where needed has the unintentional effect of making the building especially difficult to navigate.

Additionally, to cut costs, the ceiling tiles and grid were not rebuilt to accommodate the new walls, which makes for a small gap at the top and reduces noise insulation.

U.S. News & World Report ranked Centennial among the top high schools in the country, giving it a silver award.

The high performance is made more remarkable by the fact that approximately 60% of students fall into the "economically disadvantaged" category, and 15% have limited English proficiency.

These categories do not readily display the diversity present at the school, as there are many students from Eastern Europe, the Middle East, and the Horn of Africa who attend Centennial.

Although situated in a prosperous area of Columbus, the boundaries for attending stretch along a narrow corridor towards the south which encompasses a variety of neighborhoods and socioeconomic statuses.

Centennial's sports teams include Football, Basketball, Volleyball, Soccer, Baseball, Golf, Wrestling, Softball, Swimming, Track, Cross Country, Cheerleading, Bowling, Lacrosse, and Tennis.

Like most other Columbus High Schools (except for Walnut Ridge), Centennial has three tennis courts, although room was provided for a full five (which makes matches go much more quickly).