In conjunction with the University Library System, the Center created and operates PhilSci-Archive (philsci-archive.pitt.edu), a preprint server for professional work in philosophy of science.

[2] In 2016, John D. Norton stepped down after a ten-year tenure as the director of the center.

Throughout its history, the center has been associated with a number of notable individuals from philosophy of science, including nearly 300 visiting professors from more than 30 countries.

[1] The center's inaugural Annual Lecture Series included lectures from the noted philosophers Paul K. Feyerabend, Adolf Grünbaum, Carl Gustav Hempel, Ernest Nagel, Michael Scriven, and Wilfrid Sellars.

Later Annual Lecture Series participants include Herbert Feigl, Norwood Russell Hanson, Philip Morrison, Hilary Putnam, and George Wald.