CDH was the first hospital in DuPage County to perform open heart surgery and the first to perform closed-chest, robot-assisted cardiac bypass surgery in the State of Illinois.

[4] The Central DuPage Hospital Association was established in 1958 when citizens from Glen Ellyn, Lombard, Wheaton, Warrenville, Winfield and West Chicago banded together to restore a sanitarium located on the hospital's current primary site.

After an extensive million-dollar renovation project, Central DuPage Hospital opened on September 16, 1964 with 113 beds and 66 physicians.

The hospital saw much change throughout the 1970s, with the opening of a 120-bed pavilion on December 13, 1970, small additions in 1971 and 1972, and a five-story 112-bed patient tower in 1976.

[5] The facility and campus continued to expand in the decades that followed, with much of the original structure eventually reused or demolished, culminating in the construction of a new $232 million five-story bed tower with 202 private rooms in 2011.