OSF St. Joseph Medical Center is a 149-bed Level II trauma center hospital complex in Bloomington, Illinois, USA, and is part of the OSF Healthcare System.

[1] St. Joseph Hospital accepted its first patient on 1880.

The original hospital was a two-story brick mansion on Jackson Street.

The current site on East Washington Street was opened in the 1960s.

[2] Among the hospital's claims of firsts in central Illinois were the first successful Caesarian section birth;[2] the 1929 first blood transfusion; first successful radiation therapy in the 1940s;[3] the 1990 first open heart surgery;[2] and first "beating heart surgery", in which the heart is not stopped, in 2000.