The Central Illinois Conference or CIC, is a high school athletic conference in Central Illinois.

Its schools belong to the IHSA and compete in many sports and other activities.

The conference started in the 2014-15 school year and originally included Argenta-Oreana, Clinton, St. Teresa, Meridian, Central A&M, Sullivan, Shelbyville, Warrensburg-Latham, and Tuscola all schools from the Okaw Valley Conference.

Before the actual forming of the CIC, Argenta-Oreana decided to join the Little Okaw Valley Conference, so this left the new conference with 8 schools.

Sullivan abstained from the vote due to accepting an invitation to join the Lincoln Prairie Conference beginning in the 2023-24 school year.