Built in the Richardsonian Romanesque style, it served several railroad companies until the mid-20th century.
It was situated at North 7th Street and West River Road, near the Ohio River waterfront, and it was also known as the 7th Street Depot.
By 1969, only the Chesapeake and Ohio Railway's George Washington remained at the station.
[1] That train last called at the station in April 1971.
Central Station was demolished in 1972 to make way for Interstate 64.