The railroad was headquartered in Indianapolis, Indiana, in the Chesapeake Building at 105 South Meridian Street.

[1] Between 1904 and 1908 the railroad constructed a repair shop for steam locomotives and for passenger and freight cars in Beech Grove, Indiana.

[2] The railroad operated a terminal at Bellefontaine, Ohio, that included the largest roundhouse in use at that time between New York City and St. Louis, Missouri.

In 1895, the railroad acquired what became known as the Big Four Bridge across the Ohio River at Louisville, Kentucky, thereby giving it access to that city.

Use of the bridge for railroad purposes ceased by 1968, and it sat abandoned until work began by 2006 to convert it to use by pedestrians and bicyclists.