Patterson Boulevard in Downtown Memphis, it currently a service stop for Amtrak's City of New Orleans route, arriving in late evening northbound and in the morning southbound.

Between April 1, 1964, and November 30, 1966, the Louisville and Nashville Railroad was also a tenant, during the time that Memphis Union Station was closed.

After the train passed, the switchtender was found fatally injured, although the cause could not with certainty be determined to be accidental from being hit by a RPO mail hook or being murdered by a hobo in the area.

The relatives of the switchtender sued for negligence under the Federal Employers Liability Act and the Supreme Court upheld the claim.

Amtrak cut back service to a single train, the City of New Orleans, and large sections of Central Station were closed off and abandoned.

[3] In 2019 the station underwent a major $55 million remodel that included a new Amtrak ticket office and waiting area.

The MATA Trolley Main Street Line heritage streetcar was extended to Central Station in 2021.