Horn Lake is a city in DeSoto County, Mississippi, United States.

U.S Route 51 forms a large portion of Horn Lake's eastern border; it leads north 15 miles (24 km) to downtown Memphis, and south 9 miles (14 km) to Hernando, the DeSoto County seat.

Interstate 55 passes just east of Horn Lake, with access from Exits 287,289 and 901.

Revealed Horn Lake was now 56.3% non-Hispanic White (down from 83% in 2000), 33% African-American (up from 12% in 2000), 8% Hispanic, 1% Asian, 0.4% Native American, and 2.3% mixed race.

During 2001, Horn Lake annexed several square miles and about 6,000 people to the west of the city's former borders.

But, in 2011, the Mississippi Supreme Court blocked the annexation of the Town of Walls because, as the Court explained, the City of Horn Lake was experiencing economic problems, did not satisfy the requirements for annexation, and therefore did not have a need to expand.

[11] The headquarters of the American Contract Bridge League are in Horn Lake, along with a related Hall of Fame, museum, and library.

[14] The company declined an Associated Press request to tour the Horn Lake manufacturing facility.