The Central tall grasslands are a prairie ecoregion of the Midwestern United States, part of the North American Great Plains.

This ecoregion covers a large area of southern Minnesota, most of Iowa, and a narrow strip from the southeast corner of North Dakota through eastern South Dakota and eastern Nebraska to northeastern Kansas.

[2] The high rainfall and long summer allows a rich plant cover and this area was once the largest area of tallgrass prairie in the world, with grasses reaching up to 7 feet (2 m) high and interspersed with many wildflowers.

For example, 265 species of plants were recorded in Iowa, 237 in a square mile near Lincoln, Nebraska, and 225 in the Missouri River Valley.

No substantial areas of original grassland remain in this ecoregion, only fragmented remnants but prairie restoration is happening, for example, at Neal Smith National Wildlife Refuge in Jasper County, Iowa.