Its geographical range is very fragmented; it has a total area of about 20,000 km2 and is continuously shrinking due to human activities.

[1] Breeding is triggered by heavy rain fall and Pacific horned frogs reproduce explosively over the course of a single night.

Typically, Pacific horned frogs lay underground during day and they are most active after sundown.

Male frogs reproduce by approaching females both on land and shallow water and clasp on to the female, in a variation of axillary amplexus, in other word called "neck amplexus".

They also eat small fish and baby feeder mice, though they shouldn't be a staple of their diet in captivity as it can cause bloating and high fat.