Ramos was ranked by Baseball America as the tenth best prospect in the Padres organization in 2007 while going 13–9 with a 3.41 ERA for the San Antonio Missions.

On September 28, 2009 the Padres announced that Ramos would be making his first Major League start against his hometown team, the Los Angeles Dodgers.

On December 17, 2010, a deal was finalized that sent Ramos, along with Adam Russell, Brandon Gomes and Cole Figueroa, to the Tampa Bay Rays for Jason Bartlett and a player to be named later.

He spent much of the next season with the Triple–A Durham Bulls, but he appeared in 17 games for Tampa Bay and registered a 2.10 ERA over 30 innings.

After failing to make the Rangers Opening Day roster, Ramos accepted an assignment to the Triple-A Round Rock Express.

[citation needed] In 8 games (3 starts) for the Triple–A Toledo Mud Hens, he compiled a 2–3 record and 6.00 ERA with 19 strikeouts across 21 innings pitched.

[10] In 40 games (11 starts) for the Triple–A Lehigh Valley IronPigs, he registered a 5–4 record and 4.00 ERA with 74 strikeouts in 92+1⁄3 innings pitched.

Ramos was hired for the 2021 season by the Philadelphia Phillies to work with injured pitchers at their Minor League complex in Clearwater, Florida.