In his first season for Connors State, Romano pitched to a 0–1 win–loss record, 8.68 earned run average (ERA), and 14 strikeouts in 91⁄3 innings.

[3] The following season, Romano made 10 starts and posted a 4–3 record with a 4.74 ERA and 53 strikeouts in 38 innings pitched, helping get the Cowboys to the National Junior College Athletic Association (NJCAA) World Series.

Pitching as the team's closer, Romano made 29 relief appearances and posted a 3–4 record, 11 saves, 2.66 ERA, and 49 strikeouts in 402⁄3 innings.

[4] Romano was selected in the tenth round of the 2014 Major League Baseball draft by the Toronto Blue Jays.

[1] During spring training for the 2015 season, Romano tore his ulnar collateral ligament, and in April he underwent Tommy John surgery.

[11] On December 13, 2018, Romano was taken third overall in the Rule 5 draft by the Chicago White Sox and was immediately traded to the Texas Rangers for cash considerations.

[17] With the 2020 Toronto Blue Jays, Romano appeared in 15 games, compiling a 2-1 record with 1.23 ERA and 21 strikeouts in 14+2⁄3 innings pitched.

[19] On April 11, 2022, Romano set a Blue Jays club record with his 26th consecutive converted save stretching back to the 2021 season, in helping the team to a 3–0 victory over the New York Yankees.

He was charged with the blown save and loss in the Blue Jays Wild Card Game 2 defeat giving up two runs.