In creating Cesare, Soryo collaborated with Dante scholar Motoaki Hara to bring Renaissance Italy to life in great and accurate detail.

The manga takes an intimate look at Cesare's life during his matriculation at the University of Pisa, at the age of 15, in the years preceding his appointment as a cardinal of the Holy See.

[1] Its chapters were collected into 13 tankōbon (compiled volumes) published by Kodansha's KC Deluxe imprint from October 23, 2006,[5] to January 21, 2022.

[8] On June 14, 2019, Kodansha announced a stage musical adaptation of the manga directed by Yūna Koyama, with a script written by Kōichi Ogita and a score composed by Ken Shima.

[22] The musical's cast included Akinori Nakagawa as Cesare Borgia, Shuntarō Miyao as Miguel da Corella, Ryo Matsuda and Taiki Yamazaki (double cast) as Angelo da Canossa, Tetsuya Bessho as Rodrigo Borgia, Kōjirō Oka as Giuliano della Rovere, Haruki Kiyama as Raffaele Riario, Takuya Kon as Lorenzo de' Medici, Masaaki Fujioka as Dante Alighieri, and Daisuke Yokoyama as the Holy Roman Emperor Henry VII, among others.

The website featured video interviews with Fuyumi Soryo; behind-the-scenes information about the manga's production; and a user-edited wiki called Cesarepedia, a portmanteau of "Cesare" and "Wikipedia", with entries on historical figures and events.

Supervised by Soryo and Motoaki Hara, the book introduces readers to Italian history and culture during the Renaissance.