Along with Muziano's other assistant, Giovanni Guerra, they decorated the Gregorian Chapel in St Peter's Basilica during the pontificate of Gregory XIII (1572–1585).
Other Mannerist painters involved in this enterprise were Taddeo and Federico Zuccari, Niccolò Circignani, and Hendrick van den Broeck (known as Arrigo Fiammingo).
Starting in 1586, they participated in the painting of scenes from the Life of the Virgin in the church of Santa Maria Maggiore and its new Capella Sistina (not to be confused with the more famous Sistine Chapel).
During the papacy of Clement VIII he designed the pendentive mosaics depicting the Evangelists Matthew and Mark for St. Peter's Basilica.
Along with the painter known as il Bertoia, Federico Zuccari and others, he helped fresco the walls of the Oratorio del Gonfalone in Rome.