Chain of Desire is a 1992 American drama romance film written and directed by Temístocles López.

The film score was composed by Nathan Birnbaum with additional music by Peter Gordon.

[2] The Chet Baker song "So Hard To Know", written by Roxanne Seeman and Rique Pantoja, appears in the film.

[8] Richard Harrington of The Washington Post remarked the film "is an odd mix: an American update of Max Ophüls's The Circle, a sexual Slackers and an MTV-style public service announcement on AIDS stretched out to 105 minutes of tragicomedy with a heavy-handed message that works emotionally, but not at all logically.

"[3] Harrington critiqued the film’s lack of character development and concluded "in trying to create a democracy of victims who casually cross sexual, ethnic and economic lines, Lopez ends up creating unamusing comedy and unmoving tragedy.