Primarily known for his roles as Tomin in the television series Stargate SG-1 (1997–2007) and railroad entrepreneur Collis Huntington in Hell on Wheels (2011–2016), he appeared in the Marvel Cinematic Universe (MCU) feature films Iron Man (2008) and Iron Man 2 (2010) as United States Air Force Major Allen, and as struggling father and retired major Clay Wilson in the first season of the streaming television series The Punisher (2017–2019).

[4] He later attended the University of North Carolina School of the Arts in Winston-Salem, where he graduated and had his film debut.

In 2005, he starred as record producer Sam Phillips in the Golden Globe® Award-winning miniseries Elvis.

[7] He was a cast regular in AMC's Hell on Wheels, playing railroad entrepreneur Collis Huntington.

[citation needed] Guinee met his wife Daisy Foote, during the production of Hallmark Hall of Fame: Lily Dale (1996).