The Sutrakhanda is a prelude to the Krishna's appearance as the Gauranga avatar in Nabadwip, which describes the events which led to this incarnation.
The Adi Khanda narrates the early life of Chaitanya Mahaprabhu up to his trip to Gaya.
The Madhya Khanda describes events in Mahaprabhu's later life up to his meeting with Sarvabahuma Bhattacharya.
The Shesh Khanda narrates his pilgrimages to southern and northern India.
Some manuscripts also consist a description of the last part of the Mahaprabhu's life till his disappearance.