The holotype of Chamaeleo intermedius, specimen KNM-FT 3833, was discovered at a paleontological site near Fort Ternan in Kenya.

[4] Chamaeleo intermedius was a relatively small chameleon based on the fossil material, which is only 4.3 cm (1.7 in) long from the head to the middle of the torso.

However it clearly exhibits traits typically associated with the genus Chamaeleo including the higher than broad body, well developed keel along the back, large eyes, helmet-like casque, well defined parietal crest and the presence of a swollen throat pouch likely containing the characteristic projectile tongue these reptiles are known for.

The type description notes that Chamaeleo intermedius preserves no traits unique to this species, but is instead defined based on the combination of features.

The two differ however as the modern species has irregular dorsal scales, an unforked parietal crest and a head and body that are both notably broadened.

The dorsal knobs of Chamaeleon intermedius also bear resemblance to those found in some Mount Lefo chameleons.

However, in recent years the later group has been deemed distinct enough to warrant its own independent genus, now named Trioceros.