The Camara de Comercio de Manila was formally organized and presented to its General Assembly on May 24, 1887, and on June 17, 1887 its statutes and by-laws were initially approved by the Gobierno Superior of the Philippines; and finally approved by Her Majesty, the Queen Regent of Spain, Maria Cristina, on February 9, 1888.

The first organizational meeting of the founders was held at the residence of Don Juan Rodriguez on Calle Vives in San Nicolas District.

On July 17, 1933, During the 3rd session of the 9th Philippine Legislature, the Secretary of Agriculture and Commerce was authorized to sell to the Chamber a land for its building[9][10] and approved therein on December 6, 1933.

However, manifold concerns confronting the conduct of business emboldened the Chamber towards issues essential to the material progress of the country.

It was printed in a deluxe format, on heavy paper, which made it the most expensive, authoritative and exclusive trade publication in the Philippines.

In 2015, José Luis U. Yulo Jr. (56th President of the Chamber) and Denissa G. Venturanza (Executive Director) decided to revive the publication.