The Chamberlain Bridge, is a historic bridge connecting the towns of Chamberlain and Oacoma across the Missouri River and Lake Francis Case in Brule County, South Dakota.

In 1953, Lake Francis Case was created by the new Fort Randall Dam and the bridge became obsolete.

In 1923 South Dakota's bridge fund had a balance of $4 and groups from Rosebud, Chamberlain, Pierre, Forest City and Mobridge asked the state legislature to fund a bridge in their location to cross the Missouri River.

Kirkham later fulfilled his promise, building all five bridges for a total of $2.1 million.

It was built by the Missouri Valley Bridge & Iron Works of Leavenworth, Kansas and completed in September 1925 at an estimated cost of $303,623.