In 1884, when E. George Evans acquired the school, it became coeducational and changed its name to Queen City Business College.

It started new programs in social services in the 1970s, opened the Willett Foster Hall, home to the Engineering Technology Division, in 1982, and added the Hauke Family Campus Center in 1989.

In 2002, Champlain launched its first master's degree program in Managing Innovation & Information Technology.

The College's library, the Robert E. and Holly D. Miller Information Commons, opened in 1998 and in 2004 the school dedicated the S.D.

Later that year, Champlain established the Core Division, followed by the Life Experience & Action Dimension (LEAD) program in 2009.

In October 2012, Champlain College received the largest gift in its history, a gift of $10 million from the Stiller Family Foundation[5] that established the Stiller School of Business and funded the Perry Hall Welcome and Admission Center, as well as to begin work on the Center for Communications & Creative Media, which opened in the fall of 2015.

Champlain's campus consists of 42 buildings on about 2.5 city blocks in the residential Hill Section of Burlington, Vermont.

[18][19] Located 1.5 miles southwest of the main campus[20] is Miller Center and the residential student parking lot.

Miller Center also includes the Makerspace, where students access equipment such as 3D printers/scanners, laser and vinyl cutters, and power tools.

Champlain College has campuses in Dublin, Ireland and Montréal, Canada, in addition to partnerships with institutions around the world.

[22] Champlain College's Montréal campus opened its doors in 2007 with classroom space located at Rue Sherbooke Est.

The Academic Center is located at 43 Leeson Street Lower, near Dublin's Georgian Office District, and comprises four classrooms, a computer lab, and a lounge.

[24] Experiential courses teach students about Ireland's economy, music, cultural heritage, and history.

The Center for Service and Sustainability is a community service and civic engagement based club that participates in a number of activities such as Tent City (a fundraiser to raise homeless awareness and money for COTS (Committee on Temporary Shelter), and the DREAM program (a mentoring program for underprivileged children).

[34] Willard and Maple is an international literary magazine published by Champlain College, with the editorial board made up of faculty and students.