[3][obsolete source] The company's headquarters are in Nashville, Tennessee, with more than 89 additional locations throughout the United States and the world, Canada, New Zealand, Israel, Taiwan, the UK, and the Philippines.

In December 2011, Change Healthcare closed a round of financing led by Sandbox Industries, BlueCross BlueShield Venture Partners, and West Health Investment Fund.

The name was changed to Emdeon to avoid confusion with its then subsidiary WebMD, which started public trading under stock symbol WBMD in September 2005.

[19] In August 2010, the company acquired Interactive Payer Network (IPN), a technology service provider that acts as an outsourcing partner for HIPAA-compliant healthcare electronic data interchange (EDI).

[20] In October 2010, the company acquired Chamberlin Edmonds & Associates, Inc. (CEA), a technology-enabled provider of government program eligibility and enrollment services.

[21] In May 2011, the company acquired EquiClaim, a provider of healthcare audit and recovery services for commercial and government payers, from MultiPlan, Inc.[22] In August 2011, Emdeon Inc. was taken private for $3 Billion by Blackstone Group.

[23] Blackstone's offer of $19 per Emdeon share was backed by committed financing from Bank of America Merrill Lynch, Barclays Capital and Citigroup.

[26] In June 2013, the company acquired Gold Health Systems, a healthcare management organization that specializes in providing pharmacy benefits and related services primarily to State Medicaid agencies across the nation.

[46][47] On February 22, 2024, UnitedHealth Group filed a notice to the Securities and Exchange Commission stating that a "suspected nation-state associated cybersecurity threat actor" gained access to Change Healthcare's information technology system.

Following UnitedHealth Group's initial filing, CVS Health, Walgreens, Publix, GoodRX, and BlueCross BlueShield of Montana reported disruptions in insurance claims.

In the same update, the company stated that it was "working closely with law enforcement and leading third-party consultants, Mandiant and Palo Alto Networks" to address the matter.

[54] On March 1, 2024, UnitedHealth Group's Optum division launched a Temporary Funding Assistance Program to help bridge the gap in short-term cash flow needs for providers who received payments from payers that were processed by Change Healthcare.

[55][56] The American Hospital Association (AHA) stated that the program was "not even a band-aid" on the payment problems identified by the company, citing its "onerous" terms and conditions including Optum's ability to recoup funds "immediately and without prior notification", and to "change the agreement simply by providing notice.