Roe was born in Pasadena, California, but raised in Corona del Mar before training as an actor at the Joanne Baron / D.W. Brown Acting Studio and then at the British Academy of Dramatic Arts.
In 1996, Roe starred as the lead character "Cash", leader of the Gangrel Clan of vampires, in the cult television series Kindred: The Embraced.
Bio-Dome and Soldier Boys soon followed in Person's Unknown, alongside Naomi Watts, Kelly Lynch, Joe Mantegna and directed by George Hickenlooper, and Academy Award-nominated Boogie Nights.
Channon Roe has appeared in over 35 television series to date, including recurring performances such as Dirt starring Courteney Cox as Jeff Stagliano, the Indie Director who impregnates a very disturbed Shannyn Sossamon, and Windfall as Jeremy.
Roe is an avid surfer, and is highly involved with activist groups Green Peace, Heal the Bay, and Surfrider Foundation.