The charged aerosol detector (CAD) is a detector used in conjunction with high-performance liquid chromatography (HPLC) and ultra high-performance liquid chromatography (UHPLC) to measure the amount of chemicals in a sample by creating charged aerosol particles which are detected using an electrometer.
The CAD can measure all non-volatile and many semi-volatile analytes including, but not limited to, antibiotics, excipients, ions, lipids, natural products, biofuels, sugars and surfactants.
[6] At around the same time Dixon and Peterson at California State University were investigating the coupling of liquid chromatography to an earlier version of TSI's EAM technology, which they called an aerosol charge detector.
Corona ultra Corona ultra RS Dionex Corona Veo Vanquish Charged Aerosol Detector •Designed for near-universal detection on any HPLC •Isocratic or gradient separations •Heated nebulization •External gas conditioning module for improved precision •Stackable design •Enhanced sensitivity •Incorporated precision internal gas regulation system UltiMate 3000 UHPLC+ system •Added on-board diagnostics/monitoring •Automated flow diversion capability •Selection of linearization parameters rate range •Total redesign with concentric nebulization and optimized spray chamber •Heated evaporation and electronic gas regulation Scientific Vanquish UHPLC platform •Slide-in module design •Reduced flow path for optimum operation The general detection scheme [13] involves: The CAD like other aerosol detectors, can only be used with volatile mobile phases.
More detailed information on how CAD works can be found on the Charged Aerosol Detection for Liquid Chromatography Resource Center.