Charles Blair Leighton (6 March 1823 – 6 February 1855) was an English painter.
He was the father of painter Edmund Blair Leighton (1853–1922).
He was apprenticed to a silver-engraver between ages 14–21 but abandoned engraving and became a student of the Royal Academy.
He painted portraits and figure-pieces, and was an occasional exhibitor at the Royal Academy.
He married Caroline Boosey, daughter of music publisher Thomas Boosey, in April 1849 and they had two daughters and a son (the painter Edmund Blair Leighton).