Brewer split 2010 between the Single–A South Bend Silver Hawks and High–A Visalia Rawhide, accumulating an 11–8 record and 2.45 ERA with 153 strikeouts across 150+2⁄3 innings pitched.

[10] Brewer split the 2014 campaign between Double–A Mobile and Triple–A Reno, compiling an 11–12 record and 4.46 ERA with 138 strikeouts over 29 total starts.

[12] He made 5 starts split between the rookie–level Arizona League Indians and Double–A Akron RubberDucks, registering a 2.08 ERA with 14 strikeouts across 17+1⁄3 innings of work.

On April 28, 2016, Brewer signed a minor league contract to return to the Arizona Diamondbacks organization.

He made 3 appearances (2 starts) for the Double–A Mobile BayBears, logging a 1.04 ERA with 8 strikeouts over 8+2⁄3 innings pitched.