They are located in Sugar Land, Texas, part of the Greater Houston metropolitan area, and play their home games at Constellation Field.

In 2008, Sugar Land, Texas, residents voted for the allocation of civic revenues toward the construction of a new baseball park.

[3] City of Sugar Land officials contracted Opening Day Partners to build the ballpark to bring professional baseball to the region.

The American Association and United Baseball League were considered since both organizations had teams located in Texas.

The council's action cleared the way for Houston-area residents Bob and Marcie Zlotnik, who had been one-third minority partners since the 2012 season, to assume full ownership of SL Baseball, LLC.

[7] Also in the 2014 season, the Atlantic League of Professional Baseball All-Star Game was held at Constellation Field, home of the Skeeters.

The Skeeters reached the Atlantic League championship finals that season but were swept by the Lancaster Barnstormers in the best-of-five-game series, 3–0.

On September 17, 2015, the Skeeters announced the signing of former MLB All-Star Rafael Palmeiro, who had been in retirement for ten years.

Shortly after signing with the Skeeters, the elder Palmeiro said, "We discussed me playing earlier this year and it's something I've looked forward to since then.

Shortly after the conclusion of the 2017 season, Skeeters manager Gary Gaetti stepped down from his position with the expiration of his contract.

[13] In November 2020, the Sugar Land Skeeters reached an agreement with the Houston Astros to be their Triple-A affiliate beginning in the 2021 season.

[22] The new identity incorporates the team's affiliation with the Astros, Sugar Land's proximity to NASA's Johnson Space Center, and cowboy imagery.

[25] They defeated the Reno Aces, winners of the second-half, 2–0 in a best-of-three series, to win their first Pacific Coast League championship.

Before rebranding on January 31, 2022, The official colors of the Sugar Land Skeeters were imperial blue, nighttime black, rawhide yellow, white, and refinery red.

"[48] After rebranding the team to the Sugar Land Space Cowboys, the colors became "light blue, navy, orange, gray and black notes".

Their primary mascot was Swatson: a large, green mosquito who performed stunts, engaged in fan activities, and was often found throughout the stadium during games.