Charles Denison (January 23, 1818 – June 27, 1867) was a Democratic member of the U.S. House of Representatives from Pennsylvania.

He received a liberal education, and was graduated from Dickinson College in Carlisle, Pennsylvania, in 1838.

He studied law, was admitted to the bar in 1840 and commenced practice in Wilkes-Barre, Pennsylvania.

Denison was elected as a Democrat to the Thirty-eighth, Thirty-ninth, and Fortieth Congresses and served until his death in Wilkes-Barre.

He was a delegate to the 1864 Democratic National Convention.